ColdFusion makes processing uploaded files easy, a simple <CFFILE ACTION="upload"> does the trick. However, ColdFusion has not handled large files very well, large as in many hundreds of megabytes, or even gigabytes. Part of the issue was that ColdFusion kept all uploaded content in memory so as to support the GetHTTPRequestData() function.
ColdFusion 8 fixes this problem, and now supports receiving uploaded files of any size. But, if the file is large, the "content" member of the GetHTTPRequestData() structure will be empty. If you do need access to the uploaded data, simply save the file and then read it.
If you need ColdFusion 8 to always populate "content" (compatible with CFMX7 and earlier), set the system property "coldfusion.markResetForMulitPart" to "true".